Como antiarrítmico: • Dosis inicial de carga: 1,25 mg/kg i.v en infusión intermitente, cada 5 min. hasta un total de 15mg/kg. • Mantenimiento. calculo de dosis factor goteo regla de tres. CONECTAR A EQUIPO MACRO IV DIRECTA FENITOINA (EPAMIN) ANTICONVULSIVANTE. DIFENILHIDANTOINA (Fenitoina) Mecanismo de Acción: . en el hígado y el 35 % de una dosis oral aparece en la orina, vida media 4 h.

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Casilla D Temuco – Chile Tel.: Phenytoin diphenylhydantoin, dilantin has been the chosen anti-convulsive for the treatment of sudden difenolhidantoina since the late ‘s.

Teratogenic potential of almokalant, dofetilide, and d-sotalol: For both cases, the malformations are preceded by the same precocious pathological changes edema, vascular breach, hemorrhage and at last tissue necrosis during the same pregnancy phase.

Se realiza una revision actualizada y completa de la bibliografia y se citan los autores mas pertinentes. Psychiatr Clin Due to the refractory characteristics of his seizures he was put on DFH mg daily, and developed a pancerebellar syndrome.

Actualizar las hipotesis planteadas en su patogenia. The effects of phenytoin on rat development: The heads were separated from the bodies, and then sectioned longitudinally.

Diphenylhydantoin DFH is known to yield cerebellar ataxia in chronically treated epileptic patient due to cerebellar atrophy with loss of Purkinje cells. We comply with the HONcode standard for trustworthy health information – verify here. Maternal hemodynamic changes may contribute to embryonic hypoxia; however, these changes are not of such magnitude they could explain the hypoxia-related malformations by themselves Danielsson et al.


The fetal hydantoin syndrome. Cited 4 Source Add To Collection.

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Rapport 3 Estimated H-index: Selhorst JB, Kaukman B. Free radicals in disease processes: Karyometric parameters average dosix of the epithelium thorny layer cells nucleus from anterior dorsal, posterior dorsal and ventral regions of tongue of control C and treated T fetuses.

Several mechanisms have been described, with the attempt to explain the changes observed here and also those reported in literature. After surgical removal of the cyst his seizures entirely faded away dpsis his cerebellar signs improved.

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Phenytoin may also be expelled by lactation Mirkin. The posterior dorsal region of the tongue showed to be less thick, comparing to the anterior region, however, with cell morphological characteristics very similar to the anterior region and, also showed the absence of granular and horny layers Fig. Subscribe to receive email notifications whenever new articles are published. The decreased body weight of the treated fetus observed in this work reflected in the macroscopic morphological results with decreased values.

Nevertheless his neurological examination still showed trunkal and lower limbs ataxia.

Subscribe to free Drugs. In order to support the hypoxia hypothesis, the malformations induced by the phenytoin are almost all identical to those, which can be observed after uterine vessels clampage. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.


Decreased epithelium thickness and a smaller cell volume in the treated dois can be observed.

Cerebellum as a target for toxic substances. Histological aspect of the epithelium of tongue’s ventral region of control group a and treated group b. After one year of follow up his neurological picture did not change, while he was seizures free. The prickle-cell and basal doeis showed to be disorganized; the granular layer was absent as well as the horny layer, consequently Fig. Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity.

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In this work, Wistar female rats were employed in order to check the phenytoin action in the lingual epithelium as well as in the tongue muscles. The average body weight of all treated animals was 4.

Harald Masur 8 Estimated H-index: The statistical confrontation was performed employing Mann-Whitney non-parametric test. No To Shinkei Full text available only in PDF format.